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12/3/09 Development and Validation of HPLC-AMS Method for Quantification of [14C]-CC-11050 in Human Plasma
Date Posted: |
04 Dec 2009 |
Summary: |
Poster presented at AAPS Annual Conference, LA, California, November 2009 by Celgene Corporation, NJ. Validation of HPLC-AMS Method for Quantification of [14C]-CC-11050 in Human Plasma.
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Download: |
 Celgene_XceleronNov 09_AAPS Poster.pdf Download |
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The Objectives of this study were to develop and validate a robust and reproducible liquid chromatographic (HPLC) fractionation and Accelerator Mass Spectrometry (AMS) quantification method for the determination of [14C]-CC-11050 in human plasma.
HPLC-UV method showed excellent reproducibility with intra- and inter-day precision (0.84%) of the retention time (RT) for CC- 11050 and its metabolites.
AMS analysis of HPLC fractions across the chromatographic run demonstrated that the method adequately separated CC-11050 from its known metabolites.
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