Xceleron Publish Data on Quantitative Target Binding in vivo

It has been shown in a previous study using Iodine-125, that the plasma clearance of T84.66 (anticarcinoembryonic antigen, CEA) in a xenograft mouse model can be used to test for the presence of CEA-positive tumors. Transferring the technique into humans would be problematic because of the low doses of antibody required and the potential radioactive burden required to achieve sufficient assay sensitivity.
In this study, T84.66 labelled with 14C and the ultra-sensitive isotope ratio technique of accelerator mass spectrometry (AMS) used for the analysis to demonstrate quantitative determination of target binding sites of interest in vivo.